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In addition, the fleshy mass (uvula) that hangs in the back of the throat may be spilt (bifid uvula).
As affected infants age the face may lose its plumpness and become abnormally long and narrow.
While children with cri du chat syndrome are born hypotonic (low muscle tone), they tend to become hypertonic (high muscle tone) as they grow older.
Affected infants may have feeding difficulties due to low muscle tone, poor suck, and gastroesophageal reflux disease.
Most cases are thought arise from spontaneous (de novo) genetic errors very early in embryonic development.